Matthew R Reynolds,1 Jonas Nilsson,2 Örjan Åkerborg,2 Mehul Jhaveri,3 Peter Lindgren2,41Beth Israel Deaconess Medical Center, VA Boston Healthcare System, Boston, MA, USA; 2OptumInsight, Stockholm, Sweden; 3sanofi-aventis Inc, Bridgewater, NJ, USA; 4Institute of Environmental Medicine, Other Karolinska Institute, Stockholm, Swede
Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
Abstract In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity.Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897)
Cloning, Expression, Purification, and Characterization of Clostridium botulinum Neurotoxin Serotype F Domains
The use of recombinant BoNT domains has been proposed as a means to develop strategies to treat and prevent botulism.Here, details on the molecular cloning, protein EHF expression, purification, and immunoreactivity of BoNT/F domains from Clostridium botulinum are presented.Initially, full-length synthetic genes encoding recombinant BoNT/F domains
Diet-microbiome interactions influence lung function in chronic obstructive pulmonary disease
Chronic Obstructive Pulmonary Disease (COPD) affects 30 million Americans.Previous epidemiologic work has shown that diet can impact pulmonary function in those with and without COPD.Diet is also a major driver of gut microbiome composition and function.Importantly, the Other gut microbiome has also been associated with lung health (i.e., the gut-l